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Acute Lung Injury
1Anesthesiology and 5Medicine, School of Medicine, Keio University, Tokyo, 160-8582; 2Department of Medicine, Tokyo Electric Power Company Hospital, Tokyo, Japan 160-0016; 3Medical Research Service of the United States Department of Veterans Affairs, VA Puget Sound Medical Center, and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington 98108; and 4Department of Geriatric and Respiratory Medicine, School of Medicine, Tohoku University, Sendai, Japan 980-8574
Submitted 28 August 2003 ; accepted in final form 17 November 2003
Ventilation with a small tidal volume (Vt) is associated with better clinical outcomes than with a large Vt, particularly in critical settings, including acute lung injury. To determine whether Vt influences the lipopolysaccaharide (LPS) recognition pathway, we studied CD14 expression in rabbit lungs and the release of TNF-
by cultured alveolar macrophages after 240 min of ventilation with a large (20 ml/kg) vs. a small (5 ml/kg) Vt. We also applied small or large Vt to lungs instilled with 50 µg/kg of LPS. The alveolar macrophages collected after large Vt ventilation revealed a 20-fold increase in LPS-induced TNF- release compared with those collected after small Vt ventilation, whereas TNF- was undetectable without LPS stimulation. In animals ventilated with a large Vt, the expression of CD14 mRNA in whole lung homogenates and the expression of CD14 protein on alveolar macrophages, assessed by immunohistochemistry, were both significantly increased in the absence of LPS stimulation. A large Vt applied to LPS-instilled lungs increased the pulmonary albumin permeability and TNF- release into the plasma. These results suggest that mechanical stress caused by a large Vt sensitizes the lungs to endotoxin, a phenomenon that may occur partially via the upregulation of CD14.
acute lung injury; ventilator-induced lung injury
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