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This Article Full Text Full Text (PDF) All Versions of this Article: 287/1/L79    most recent 00425.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (12) Citing Articles via Google Scholar Google Scholar Articles by Goto, Y. Articles by van Eeden, S. F. Search for Related Content PubMed PubMed Citation Articles by Goto, Y. Articles by van Eeden, S. F.

Exposure to ambient particles accelerates monocyte release from bone marrow in atherosclerotic rabbits

¹James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia V6Z 1Y6; and ²Environmental Health Directorate, Health Canada, Ottawa, Ontario, Canada K1A 0L2

Submitted 2 December 2003 ; accepted in final form 27 February 2004

Exposure to air pollution [particulate matter, particles <10 µm (PM₁₀)] causes a systemic inflammatory response that includes stimulation of the bone marrow (BM) and progression of atherosclerosis. Monocytes are known to play a key role in atherogenesis by migration into subendothelial lesions where they appear as foam cells. The present study was designed to quantify the BM monocyte response in Watanabe heritable hyperlipidemic (WHHL) rabbits after PM₁₀ exposure. WHHL rabbits were given twice weekly intrapharyngeal instillations of 5 mg of PM₁₀ for 4 wk to a total of 40 mg and compared with control WHHL or New Zealand White (NZW) rabbits. The thymidine analog 5'-bromo-2'-deoxyuridine was used to label dividing cells in the BM and a monoclonal antibody to identify monocytes in peripheral blood. The transit time of monocytes through the BM was faster in WHHL than in NZW rabbits (30.4 ± 1.9 h vs. 35.2 ± 0.9 h, WHHL vs. NZW; P < 0.05). PM₁₀ instillation exposure increased circulating band cell counts, caused rapid release of monocytes from the BM, and further shortened their transit time through the BM to 23.2 ± 1.6 h (P < 0.05). The percentage of alveolar macrophages containing particles in the lung correlated with the BM transit time of monocytes (r² = 0.45, P <0.05). We conclude that atherosclerosis increases the release of monocytes from the BM, and PM₁₀ exposure accelerates this process in relation to the amount of particles phagocytosed by alveolar macrophages.

air pollution; alveolar macrophages; atherosclerosis; inflammation; leukocytes

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