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Am J Physiol Lung Cell Mol Physiol 294: L601-L611, 2008. First published January 4, 2008; doi:10.1152/ajplung.00320.2007
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INVITED REVIEW

Apoptosis in the lung: induction, clearance and detection

P. M. Henson and R. M. Tuder

Department of Pediatrics, National Jewish Medical and Research Center, and Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Pathology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado

Apoptosis and other forms of programmed cell death are important contributors to lung pathophysiology. In this brief review, we discuss some of the implications of finding apoptotic cells in the lung and methods for their detection. The balance between induction of apoptosis and the normally highly efficient clearance of such cells shows that these are highly dynamic processes and suggests that abnormalities of apoptotic cell clearance may be an alternative explanation for their detection. Because recognition of apoptotic cells by other lung cells has additional effects on inflammation, immunity, and tissue repair, local responses to the dying cells may also have important consequences in addition to the cell death itself.

efferocytosis; inflammation


Address for reprint requests and other correspondence: P. M. Henson, Dept. of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson St., Denver, CO 80206 (e-mail: hensonp{at}njc.org)




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