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Am J Physiol Lung Cell Mol Physiol 295: L1-L15, 2008. First published May 2, 2008; doi:10.1152/ajplung.90200.2008 Free Article
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INVITED REVIEW

ANIMAL MODELS OF HUMAN LUNG DISEASE

Animal models of chronic obstructive pulmonary disease

Joanne L. Wright,1 Manuel Cosio,2 and Andrew Churg1

1Department of Pathology, University of British Columbia, Vancouver, British Columbia; and 2Respiratory Division, Royal Victoria Hospital, and Meakins-Christie Laboratories, McGill University, Montreal, Quebec, Canada

The mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD) are poorly defined. This area is complicated and difficult to model because COPD consists of four separate anatomic lesions (emphysema, small airway remodeling, pulmonary hypertension, and chronic bronchitis) and a functional lesion, acute exacerbation; moreover, the disease in humans develops over decades. This review discusses the various animal models that have been used to attempt to recreate human COPD and the advantages and disadvantages of each. None of the models reproduces the exact changes seen in humans, but cigarette smoke-induced disease appears to come the closest, and genetically modified animals also, in some instances, shed light on processes that appear to play a role.

chronic obstructive pulmonary disease


Address for reprint requests and other correspondence: J. L. Wright, Dept. of Pathology, Univ. of British Columbia, 2211 Wesbrook Mall, Vancouver, B. C., Canada V6T 2B5 (e-mail: jlwright{at}interchange.ubc.ca)




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