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Am J Physiol Lung Cell Mol Physiol 296: L109-L114, 2009. First published October 17, 2008; doi:10.1152/ajplung.00487.2007
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Alcohol feeding blocks methacholine-induced airway responsiveness in mice

P. J. Oldenburg,1 T. A. Wyatt,1,2 P. H. Factor,3 and J. H. Sisson1

1Department of Internal Medicine, Pulmonary, Critical Care, Sleep, and Allergy Section, University of Nebraska Medical Center, and 2Research Service, Department of Veterans Affairs, Omaha, Nebraska; and 3New York Presbyterian Hospital, Section of Pulmonary, Allergy, and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, New York

Submitted 27 November 2007 ; accepted in final form 16 October 2008

Historical accounts of alcohol administration to patients with breathing problems suggest that alcohol may have bronchodilating properties. We hypothesized that acute alcohol exposure will alter airway responsiveness (AR) in mice. To test this hypothesis, C57BL/6 mice were fed either 20% alcohol in drinking water (fed) or received a single intraperitoneal (ip) injection of alcohol (3 g/kg). Control groups received regular drinking water or ip saline. AR was assessed by means of ventilation or barometric plethysmography and reported as either total lung resistance or enhanced pause for each group of mice. To confirm alcohol exposure, elevated blood alcohol levels were documented. Alcohol feeding significantly blocked methacholine-triggered AR compared with water-fed controls. Comparable blunting of AR was also accomplished through a single ip injection of alcohol when compared with saline-injected controls. The alcohol response was slowly reversible in both routes of administration after withdrawal of alcohol: AR attenuation by alcohol persisted 12–20 h (ip) or up to 2 wk (fed) after blood alcohol cleared consistent with a sustained bronchodilator effect. These data demonstrate that brief alcohol exposure blunts AR in this murine model of alcohol exposure suggesting a role for alcohol in the modulation of bronchial motor tone.

enhanced pause; bronchodilator effect; Penh


Address for reprint requests and other correspondence: J. H. Sisson, 985300 Nebraska Medical Center, Univ. of Nebraska Medical Center, Omaha, NE (e-mail: jsisson{at}unmc.edu)




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J. A. Poole, T. A. Wyatt, P. J. Oldenburg, M. K. Elliott, W. W. West, J. H. Sisson, S. G. Von Essen, and D. J. Romberger
Intranasal organic dust exposure-induced airway adaptation response marked by persistent lung inflammation and pathology in mice
Am J Physiol Lung Cell Mol Physiol, June 1, 2009; 296(6): L1085 - L1095.
[Abstract] [Full Text] [PDF]


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