The major role of red blood cells (RBC) is to deliver oxygen and remove carbon dioxide within organisms through the unique properties of hemoglobin. Although beneficial within RBCs, hemoglobin and its breakdown products (heme, iron) have been found to induce pro-inflammatory responses affecting various cellular responses. Although these effects are considered to be prominent in disorders with increased hemolysis, recent evidence suggests that this process may be active in non-hemolytic disorders such as acute lung injury/ARDS. This perspectives article focuses on data related to red cell products in non-hemolytic disorders and the potential to target these factors in acute lung injury/ARDS.
- nitric oxide
- Copyright © 2016, American Journal of Physiology-Lung Cellular and Molecular Physiology