The pulmonary endothelium is the target of continuous physiologic and pathologic stimuli that affect its crucial barrier function. The regulation, defense and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.
- barrier unction
- Copyright © 2016, American Journal of Physiology-Lung Cellular and Molecular Physiology