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![]() [Cover Caption] Other Issues: |
Contents: Volume 276, Issue 5
May 1999 [Index by Author]
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Cover: Spheroids derived
as tissue explants from human airway epithelium, formed by 1 layer of
polarized epithelial cells, with apical, ciliated membrane facing
outward and basolateral membrane facing the fluid-filled lumen.
Spheroids are inflated because of an inward ion transport followed by
water. Top: experimental setup for transepithelial potential
difference measurement, with holding pipette (left) and
approaching micropipette (right). Focus is at periphery of the
spheroid (~275-µm diam; Nikon Coolpix 900 and Diaphot 300).
Bottom: broken spheroid illustrates epithelial monolayer and
empty lumen (~225-µm diam; scanning electron microscopy). From P. S. Pedersen, O. Frederiksen, N.-H. Holstein-Rathlou, P. L. Larsen, and
K. Qvortrup. Ion transport in epithelial spheroids derived from human
airway cells. Am. J. Physiol. 276 (Lung Cell. Mol.
Physiol. 20): L75-L80, 1999.
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