ANIMAL MODELS OF HUMAN LUNG DISEASE:

Joanne L. Wright, Manuel Cosio, and Andrew Churg

Animal models of chronic obstructive pulmonary disease
Am J Physiol Lung Cell Mol Physiol 295: L1-L15, 2008. First published May 2, 2008; doi:10.1152/ajplung.90200.2008 [Abstract] [Full Text] [PDF]  

TRANSLATIONAL PHYSIOLOGY:

Robert E. Gerszten, Frank Accurso, Gordon R. Bernard, Richard M. Caprioli, Eric W. Klee, George G. Klee, Iftikhar Kullo, Theresa A. Laguna, Frederick P. Roth, Marc Sabatine, Pothur Srinivas, Thomas J. Wang, Lorraine B. Ware for the NHLBI Clinical Proteomics Programs

Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs
Am J Physiol Lung Cell Mol Physiol 295: L16-L22, 2008. First published May 2, 2008; doi:10.1152/ajplung.00044.2008 [Abstract] [Full Text] [PDF]  

EDITORIAL FOCUS:

David W. Reid, Gregory J. Anderson, and Iain L. Lamont

Cystic fibrosis: ironing out the problem of infection?
Am J Physiol Lung Cell Mol Physiol 295: L23-L24, 2008. First published May 16, 2008; doi:10.1152/ajplung.90299.2008 [Full Text] [PDF]  

Sophie Moreau-Marquis, Jennifer M. Bomberger, Gregory G. Anderson, Agnieszka Swiatecka-Urban, Siying Ye, George A. O'Toole, and Bruce A. Stanton

The F508-CFTR mutation results in increased biofilm formation by Pseudomonas aeruginosa by increasing iron availability
Am J Physiol Lung Cell Mol Physiol 295: L25-L37, 2008. First published March 21, 2008; doi:10.1152/ajplung.00391.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

ARTICLES:

Olivia M. Granillo, Mulugu V. Brahmajothi, Sheng Li, A. Richard Whorton, S. Nicholas Mason, Timothy J. McMahon, and Richard L. Auten

Pulmonary alveolar epithelial uptake of S-nitrosothiols is regulated by L-type amino acid transporter
Am J Physiol Lung Cell Mol Physiol 295: L38-L43, 2008. First published April 25, 2008; doi:10.1152/ajplung.00280.2007 [Abstract] [Full Text] [PDF]  

Irina Petrache, Terry R. Medler, Amy T. Richter, Krzysztof Kamocki, Ugonma Chukwueke, Lijie Zhen, Yuan Gu, Jeremy Adamowicz, Kelly S. Schweitzer, Walter C. Hubbard, Evgeny V. Berdyshev, Giuseppe Lungarella, and Rubin M. Tuder

Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide
Am J Physiol Lung Cell Mol Physiol 295: L44-L53, 2008. First published April 25, 2008; doi:10.1152/ajplung.00448.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Ajay A. Wagh, Esra Roan, Kenneth E. Chapman, Leena P. Desai, David A. Rendon, Eugene C. Eckstein, and Christopher M. Waters

Localized elasticity measured in epithelial cells migrating at a wound edge using atomic force microscopy
Am J Physiol Lung Cell Mol Physiol 295: L54-L60, 2008. First published May 16, 2008; doi:10.1152/ajplung.00475.2007 [Abstract] [Full Text] [PDF]  

Amy L. Firth, Kathryn H. Yuill, and Sergey V. Smirnov

Mitochondria-dependent regulation of Kv currents in rat pulmonary artery smooth muscle cells
Am J Physiol Lung Cell Mol Physiol 295: L61-L70, 2008. First published May 9, 2008; doi:10.1152/ajplung.90243.2008 [Abstract] [Full Text] [PDF]  

Noriyuki Homma, Tetsutaro Nagaoka, Vijaya Karoor, Masatoshi Imamura, Laimute Taraseviciene-Stewart, Lori A. Walker, Karen A. Fagan, Ivan F. McMurtry, and Masahiko Oka

Involvement of RhoA/Rho kinase signaling in protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats by dehydroepiandrosterone
Am J Physiol Lung Cell Mol Physiol 295: L71-L78, 2008. First published May 9, 2008; doi:10.1152/ajplung.90251.2008 [Abstract] [Full Text] [PDF]  

Eiji Tamagawa, Ni Bai, Kiyoshi Morimoto, Claire Gray, Tammy Mui, Kazuhiro Yatera, Xuekui Zhang, Li Xing, Yuexin Li, Ismail Laher, Don D. Sin, S. F. Paul Man, and Stephan F. van Eeden

Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction
Am J Physiol Lung Cell Mol Physiol 295: L79-L85, 2008. First published May 9, 2008; doi:10.1152/ajplung.00048.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures and Tables]  

Namasivayam Ambalavanan, Teodora Nicola, James Hagood, Arlene Bulger, Rosa Serra, Joanne Murphy-Ullrich, Suzanne Oparil, and Yiu-Fai Chen

Transforming growth factor-β signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung
Am J Physiol Lung Cell Mol Physiol 295: L86-L95, 2008. First published May 16, 2008; doi:10.1152/ajplung.00534.2007 [Abstract] [Full Text] [PDF]  

Viktor Brovkovych, Xiao-Pei Gao, Evan Ong, Svitlana Brovkovych, Marie-Luise Brennan, Xiao Su, Stanley L. Hazen, Asrar B. Malik, and Randal A. Skidgel

Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice
Am J Physiol Lung Cell Mol Physiol 295: L96-L103, 2008. First published April 18, 2008; doi:10.1152/ajplung.00450.2007 [Abstract] [Full Text] [PDF]  

Wenju Lu, Jian Wang, Larissa A. Shimoda, and J. T. Sylvester

Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca²⁺ responses to hypoxia
Am J Physiol Lung Cell Mol Physiol 295: L104-L113, 2008. First published April 18, 2008; doi:10.1152/ajplung.00058.2008 [Abstract] [Full Text] [PDF]  

Megan N. Ballinger, Leah L. N. Hubbard, Tracy R. McMillan, Galen B. Toews, Marc Peters-Golden, Robert Paine, III, and Bethany B. Moore

Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation
Am J Physiol Lung Cell Mol Physiol 295: L114-L122, 2008. First published May 2, 2008; doi:10.1152/ajplung.00309.2007 [Abstract] [Full Text] [PDF]  

Qing Lu

Transforming growth factor-β1 protects against pulmonary artery endothelial cell apoptosis via ALK5
Am J Physiol Lung Cell Mol Physiol 295: L123-L133, 2008. First published May 2, 2008; doi:10.1152/ajplung.00402.2007 [Abstract] [Full Text] [PDF] [Supplemental Figures]  

Dirk Haufe, Eva Koenigshausen, Lilla Knels, Martina Wendel, Sebastian N. Stehr, and Thea Koch

Leukocyte antibacterial functions are not impaired by perfluorocarbon exposure in vitro
Am J Physiol Lung Cell Mol Physiol 295: L134-L142, 2008. First published May 2, 2008; doi:10.1152/ajplung.00338.2007 [Abstract] [Full Text] [PDF]  

Shenghong Yang, Matthew A. Nugent, and Mikhail P. Panchenko

EGF antagonizes TGF-β-induced tropoelastin expression in lung fibroblasts via stabilization of Smad corepressor TGIF
Am J Physiol Lung Cell Mol Physiol 295: L143-L151, 2008. First published April 25, 2008; doi:10.1152/ajplung.00289.2007 [Abstract] [Full Text] [PDF]  

Natalie J. Serkova, Zachary Van Rheen, Meghan Tobias, Joshua E. Pitzer, J. Erby Wilkinson, and Kathleen A. Stringer

Utility of magnetic resonance imaging and nuclear magnetic resonance-based metabolomics for quantification of inflammatory lung injury
Am J Physiol Lung Cell Mol Physiol 295: L152-L161, 2008. First published April 25, 2008; doi:10.1152/ajplung.00515.2007 [Abstract] [Full Text] [PDF]  

J. Xu, F. Xu, and E. Barrett

Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice
Am J Physiol Lung Cell Mol Physiol 295: L162-L170, 2008. First published April 25, 2008; doi:10.1152/ajplung.00282.2007 [Abstract] [Full Text] [PDF]  

Barry Moynihan, Barbara Tolloczko, Marie-Claire Michoud, Meiyo Tamaoka, Pasquale Ferraro, and James G. Martin

MAP kinases mediate interleukin-13 effects on calcium signaling in human airway smooth muscle cells
Am J Physiol Lung Cell Mol Physiol 295: L171-L177, 2008. First published April 25, 2008; doi:10.1152/ajplung.00457.2007 [Abstract] [Full Text] [PDF]  

Xiaopeng Li, Maria Molina-Molina, Amal Abdul-Hafez, Victor Uhal, Antonio Xaubet, and Bruce D. Uhal

Angiotensin converting enzyme-2 is protective but downregulated in human and experimental lung fibrosis
Am J Physiol Lung Cell Mol Physiol 295: L178-L185, 2008. First published April 25, 2008; doi:10.1152/ajplung.00009.2008 [Abstract] [Full Text] [PDF]  

Bit Na Kang, Joseph A. Jude, Reynold A. Panettieri, Jr., Timothy F. Walseth, and Mathur S. Kannan

Glucocorticoid regulation of CD38 expression in human airway smooth muscle cells: role of dual specificity phosphatase 1
Am J Physiol Lung Cell Mol Physiol 295: L186-L193, 2008. First published April 25, 2008; doi:10.1152/ajplung.00352.2007 [Abstract] [Full Text] [PDF]  

Ashwini S. Sabnis, Christopher A. Reilly, John M. Veranth, and Garold S. Yost

Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures
Am J Physiol Lung Cell Mol Physiol 295: L194-L200, 2008. First published April 25, 2008; doi:10.1152/ajplung.00072.2008 [Abstract] [Full Text] [PDF]  

Anne-Christine Peyter, Vincent Muehlethaler, Lucas Liaudet, Mathieu Marino, Stefano Di Bernardo, Giacomo Diaceri, and Jean-François Tolsa

Muscarinic receptor M₁ and phosphodiesterase 1 are key determinants in pulmonary vascular dysfunction following perinatal hypoxia in mice
Am J Physiol Lung Cell Mol Physiol 295: L201-L213, 2008. First published May 9, 2008; doi:10.1152/ajplung.00264.2007 [Abstract] [Full Text] [PDF]  

Dedmer Schaafsma, I. Sophie T. Bos, Annet B. Zuidhof, Johan Zaagsma, and Herman Meurs

The inhaled Rho kinase inhibitor Y-27632 protects against allergen-induced acute bronchoconstriction, airway hyperresponsiveness, and inflammation
Am J Physiol Lung Cell Mol Physiol 295: L214-L219, 2008. First published May 16, 2008; doi:10.1152/ajplung.00498.2007 [Abstract] [Full Text] [PDF]  

Kathryn Chmura, Xiyuan Bai, Mari Nakamura, Pitchaimani Kandasamy, Mischa McGibney, Koji Kuronuma, Hiroki Mitsuzawa, Dennis R. Voelker, and Edward D. Chan

Induction of IL-8 by Mycoplasma pneumoniae membrane in BEAS-2B cells
Am J Physiol Lung Cell Mol Physiol 295: L220-L230, 2008. First published May 16, 2008; doi:10.1152/ajplung.90204.2008 [Abstract] [Full Text] [PDF]  

REPORT:

Emma L. Rawlins and Brigid L. M. Hogan

Ciliated epithelial cell lifespan in the mouse trachea and lung
Am J Physiol Lung Cell Mol Physiol 295: L231-L234, 2008. First published May 16, 2008; doi:10.1152/ajplung.90209.2008 [Abstract] [Full Text] [PDF]  

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