Table 1.

Characteristics of each experimental group

Experiment Group20 days36 days52 days100 days160 days
PCMRI/Echo/micro-CT/Histology (same group of animals followed longitudinally)
Banded
    Number of animalsn = 13*n = 14n = 14n = 14n = 14
    Body weight, g45 ± 5152 ± 10276 ± 12503 ± 40583 ± 46
    Heart rate, beats/min455 ± 27430 ± 25392 ± 21344 ± 25333 ± 34
    MPA diameter, mm0.18 ± 0.020.26 ± 0.020.29 ± 0.030.38 ± 0.020.39 ± 0.02
    Aorta diameter, mm0.15 ± 0.010.25 ± 0.010.28 ± 0.010.33 ± 0.020.34 ± 0.02
Sham-operated
    Number of animalsn = 10*n = 12n = 12n = 12n = 12
    Body weight, g43 ± 6120 ± 14278 ± 17504 ± 52590 ± 63
    Heart rate, beats/min439 ± 42434 ± 25415 ± 28320 ± 49333 ± 37
    MPA diameter, mm0.18 ± 0.020.26 ± 0.020.29 ± 0.020.37 ± 0.030.40 ± 0.03
    Aorta diameter, mm0.15 ± 0.010.24 ± 0.010.30 ± 0.030.33 ± 0.020.35 ± 0.02
RV hypertrophy (different groups of animals at different time points)
Banded
    Number of animalsn = 6n = 6
    Body weight, g528 ± 58609 ± 39
    RV mass, g0.23 ± 0.010.23 ± 0.02
    LV+S mass, g0.89 ± 0.090.97 ± 0.08
Sham-operated
    Number of animalsn = 6n = 6
    Body weight, g514 ± 35623 ± 94
    RV mass, g0.20 ± 0.040.20 ± 0.03
    LV + S mass, g0.96 ± 0.190.98 ± 0.12
  • Values are means ± SD. One of the 13 sham-operated animals was excluded from the study due to observed hematoma in the lungs starting at age 36 days. PCMRI, phase-contrast magnetic resonance imaging; CT, computer tomography; RV, right ventricle; LV + S, left ventricle and septum; MPA, main pulmonary artery.

  • * At 20 days, equipment failure prevented flow measurements in one banded animal and two sham-operated animals.